Slide 1:
Hed: Treatment of primary hyperoxaluria
Dek: This rare condition causes kidney stones and possibly kidney damage. Find out more about your treatment options.
Slide 2:
Primary hyperoxaluria is a rare genetic disorder in which your body produces too much of a substance called oxalate.
When too much oxalate builds up in the kidneys and combines with calcium, kidney stones form, which in turn can cause kidney failure.
Slide 3:
There are three types of HP:
HP1
HP2
HP3
Therapeutic options depend on what type of PH you have. However, the therapeutic goal in all types of PH is to prevent the buildup of oxalate in the kidneys and other parts of your body.
Slide 4:
Some therapy and management options include:
Vitamin B6 (pyridoxine)
High doses of vitamin B6 can be helpful in lowering oxalate levels. This treatment works for about 3 out of 10 people. It is only useful for patients with HP1.
Slide 5:
Prescription medications
Lumasiran and nedosiran can be given as injections under the skin to lower oxalate levels. These medications are only useful for patients with HP1.
Slide 6:
Drink plenty of fluids
Drinking plenty of fluids (especially water) every day can be helpful in flushing oxalate from your body.
Slide 7:
Citrate or bicarbonate salts
Too much acid in the urine increases the risk of kidney stones. Consume citrate and bicarbonate salts such as:
Potassium citrate
Potassium bicarbonate
Sodium citrate
baking powder
It can reduce the acidity of your urine.
Slide 8:
Avoid high amounts of vitamin C
Too much vitamin C in your diet, from foods or supplements, can increase oxalate levels.
Slide 9:
Avoid foods high in oxalate
Foods high in oxalates include:
Dried fruits
Chocolate
sweet potato
Plums
Beets
rhubarb
spinach
tofu
Strawberries
If you choose to eat these foods, also consume foods high in calcium to prevent oxalate from entering your kidneys and causing kidney stones.
Slide 10:
The effectiveness of treatment for primary hyperoxaluria depends on your general health and the severity of your disease.
Talk to your doctor to find out what might be right for you.
This educational resource was created with support from Alnylam.
